Planning and Spatial Working Memory: a Positron Emission Tomography Study in Humans
Identifieur interne : 003E20 ( Main/Exploration ); précédent : 003E19; suivant : 003E21Planning and Spatial Working Memory: a Positron Emission Tomography Study in Humans
Auteurs : Adrian M. Owen [Canada] ; Julien Doyon [Canada] ; Michael Petrides [Canada] ; Alan C. Evans [Canada]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 1996-02.
English descriptors
- KwdEn :
Abstract
Previous work with both neurosurgical and neurodegenerative patient groups has suggested that high level planning is mediated by neural circuitry which includes both the prefrontal cortex and the striatum. In this study, the functional anatomy of cognitive planning was investigated further, using positron emission tomography (PET). Regional cerebral blood flow (rCBF) was measured in 12 normal volunteers while performing easy and difficult versions of (i) a modified Tower of London planning task; (ii) a mnemonic variant of this task that required short‐term retention and reproduction of problem solutions; and (iii) a control condition that involved identical visual stimuli and motor responses. Significant increases in rCBF were observed in the left hemisphere, in both the mid‐dorsolateral frontal cortex and in the head of the caudate nucleus, when the difficult planning task was compared with the control condition. Moreover, subtraction of a simple planning condition from the more difficult one revealed focal increases in rCBF in the caudate nucleus and the thalamus only. During both mnemonic variants of the planning task, changes were also observed in the mid‐dorsolateral frontal cortex and in more ventral frontopolar regions, bilaterally. When compared directly, the planning and memory conditions differed in terms of these ventral activation foci, but not in the pattern of activation observed in the mid‐dorsolateral frontal cortex. These findings further implicate frontostriatal circuitry in high‐level planning and provide evidence for functionally distinct contributions from ventral and dorsolateral frontal regions to spatial working memory.
Url:
DOI: 10.1111/j.1460-9568.1996.tb01219.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000E31
- to stream Istex, to step Curation: 000E31
- to stream Istex, to step Checkpoint: 001830
- to stream Main, to step Merge: 004510
- to stream Main, to step Curation: 003E20
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Planning and Spatial Working Memory: a Positron Emission Tomography Study in Humans</title><author><name sortKey="Owen, Adrian M" sort="Owen, Adrian M" uniqKey="Owen A" first="Adrian M." last="Owen">Adrian M. Owen</name></author><author><name sortKey="Doyon, Julien" sort="Doyon, Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name></author><author><name sortKey="Petrides, Michael" sort="Petrides, Michael" uniqKey="Petrides M" first="Michael" last="Petrides">Michael Petrides</name></author><author><name sortKey="Evans, Alan C" sort="Evans, Alan C" uniqKey="Evans A" first="Alan C." last="Evans">Alan C. Evans</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8D68D4706276416A81100F5ACE751A8A3819A922</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1111/j.1460-9568.1996.tb01219.x</idno><idno type="url">https://api-v5.istex.fr/document/8D68D4706276416A81100F5ACE751A8A3819A922/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000E31</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E31</idno><idno type="wicri:Area/Istex/Curation">000E31</idno><idno type="wicri:Area/Istex/Checkpoint">001830</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001830</idno><idno type="wicri:doubleKey">0953-816X:1996:Owen A:planning:and:spatial</idno><idno type="wicri:Area/Main/Merge">004510</idno><idno type="wicri:Area/Main/Curation">003E20</idno><idno type="wicri:Area/Main/Exploration">003E20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Planning and Spatial Working Memory: a Positron Emission Tomography Study in Humans</title><author><name sortKey="Owen, Adrian M" sort="Owen, Adrian M" uniqKey="Owen A" first="Adrian M." last="Owen">Adrian M. Owen</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea> Dr Adrian M. Owen, Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Doyon, Julien" sort="Doyon, Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology and Research Center in Neurobiology, Laval University, Quebec City, Quebec G1K 7P4</wicri:regionArea><wicri:noRegion>Quebec G1K 7P4</wicri:noRegion></affiliation></author><author><name sortKey="Petrides, Michael" sort="Petrides, Michael" uniqKey="Petrides M" first="Michael" last="Petrides">Michael Petrides</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Evans, Alan C" sort="Evans, Alan C" uniqKey="Evans A" first="Alan C." last="Evans">Alan C. Evans</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1996-02">1996-02</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="353">353</biblScope><biblScope unit="page" to="364">364</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">8D68D4706276416A81100F5ACE751A8A3819A922</idno><idno type="DOI">10.1111/j.1460-9568.1996.tb01219.x</idno><idno type="ArticleID">EJN353</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>caudate nucleus</term><term>frontal cortex</term><term>humans</term><term>striatum</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous work with both neurosurgical and neurodegenerative patient groups has suggested that high level planning is mediated by neural circuitry which includes both the prefrontal cortex and the striatum. In this study, the functional anatomy of cognitive planning was investigated further, using positron emission tomography (PET). Regional cerebral blood flow (rCBF) was measured in 12 normal volunteers while performing easy and difficult versions of (i) a modified Tower of London planning task; (ii) a mnemonic variant of this task that required short‐term retention and reproduction of problem solutions; and (iii) a control condition that involved identical visual stimuli and motor responses. Significant increases in rCBF were observed in the left hemisphere, in both the mid‐dorsolateral frontal cortex and in the head of the caudate nucleus, when the difficult planning task was compared with the control condition. Moreover, subtraction of a simple planning condition from the more difficult one revealed focal increases in rCBF in the caudate nucleus and the thalamus only. During both mnemonic variants of the planning task, changes were also observed in the mid‐dorsolateral frontal cortex and in more ventral frontopolar regions, bilaterally. When compared directly, the planning and memory conditions differed in terms of these ventral activation foci, but not in the pattern of activation observed in the mid‐dorsolateral frontal cortex. These findings further implicate frontostriatal circuitry in high‐level planning and provide evidence for functionally distinct contributions from ventral and dorsolateral frontal regions to spatial working memory.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Owen, Adrian M" sort="Owen, Adrian M" uniqKey="Owen A" first="Adrian M." last="Owen">Adrian M. Owen</name></region><name sortKey="Doyon, Julien" sort="Doyon, Julien" uniqKey="Doyon J" first="Julien" last="Doyon">Julien Doyon</name><name sortKey="Evans, Alan C" sort="Evans, Alan C" uniqKey="Evans A" first="Alan C." last="Evans">Alan C. Evans</name><name sortKey="Owen, Adrian M" sort="Owen, Adrian M" uniqKey="Owen A" first="Adrian M." last="Owen">Adrian M. Owen</name><name sortKey="Petrides, Michael" sort="Petrides, Michael" uniqKey="Petrides M" first="Michael" last="Petrides">Michael Petrides</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003E20 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003E20 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:8D68D4706276416A81100F5ACE751A8A3819A922
|texte= Planning and Spatial Working Memory: a Positron Emission Tomography Study in Humans
}}
| This area was generated with Dilib version V0.6.29. |  |